Beilstein J. Nanotechnol.2016,7, 697–707, doi:10.3762/bjnano.7.62
composite DNA nanostructures by the self-assembly of complementary symmetrical 2,6,14-triptycenetripropiolicacid (TPA)–DNA building blocks and zinc protoporphyrin IX (Zn PpIX). DNA–organic molecule scaffolds for the composite DNA nanostructure were constructed through covalent conjugation of TPA with 5
therapy (PDT) applications as well as photocatalytic reactions.
Keywords: DNA nanostructure; DNA–organic hybrid; DNA self-assembly; 2,6,14-triptycenetripropiolicacid; zinc protoporphyrin IX; Introduction
Hybrid nanomaterials resulting from the covalent conjugation of DNA with organic molecules [1][2][3
polymeric networks [46][47].
In this study, we report the synthesis of the DNA–TPA scaffolds by covalent conjugation of 2,6,14-triptycenetripropiolicacid (TPA) with amine-modified 12-mer ssDNA and coassembly with zinc protoporphyrin IX(Zn PpIX) to form composite DNA nanostructures (Scheme 1). Porphyrins
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Scheme 1:
Schematic representation of creation of nanostructures from DNA–TPA hybrid self-assembly. The numbe...